Deletion of H-ferritin in macrophages alleviates obesity and diabetes induced by high-fat diet in mice.
Yasumasa IkedaHiroaki WatanabeTetsuya ShiuchiHirofumi HamanoYuya HorinouchiMasaki ImanishiMitsuhiro GodaYoshito ZamamiKenshi TakechiYuki Izawa-IshizawaLicht MiyamotoKeisuke IshizawaKen-Ichi AiharaKoichiro TsuchiyaToshiaki TamakiPublished in: Diabetologia (2020)
Deletion of macrophage H-ferritin suppresses the inflammatory response by reducing intracellular iron levels, resulting in the prevention of HFD-induced obesity and diabetes. The findings from this study highlight macrophage iron levels as a potential therapeutic target for obesity and diabetes.
Keyphrases
- high fat diet
- insulin resistance
- type diabetes
- high fat diet induced
- adipose tissue
- glycemic control
- metabolic syndrome
- cardiovascular disease
- inflammatory response
- weight loss
- skeletal muscle
- iron deficiency
- weight gain
- high glucose
- physical activity
- immune response
- lipopolysaccharide induced
- reactive oxygen species
- climate change
- endothelial cells
- mouse model