Induction of Apoptosis and Modulation of Caspase Activity on MCF-7 Human Breast Cancer Cells by Bioactive Fractionated Cocoa Leaf Extract.

Yazan K H RannehMohd Fadzelly Abu BakarAbdah Md AkimZainal Bin BaharumMohammed S ElluluAbdulmannan Fadel

Published in: Asian Pacific journal of cancer prevention : APJCP (2023)

Overall, this study suggests that bioactive fraction (II-F7) from CL extract has significant and selective cytotoxicity against MCF-7 cells through inducing apoptosis and has potential as a therapeutic agent for breast cancer treatment.

Keyphrases

breast cancer cells
cell cycle arrest
cell death
induced apoptosis
endoplasmic reticulum stress
oxidative stress
pi k akt
endothelial cells
signaling pathway
small cell lung cancer
cell proliferation
risk assessment
anti inflammatory
human health
climate change