Cleavage by MMP-13 renders VWF unable to bind to collagen but increases its platelet reactivity.

Joanna-Marie HowesVera KnäuperJean-Daniel MalcorRichard W Farndale

Published in: Journal of thrombosis and haemostasis : JTH (2020)

Our data suggest a VWF-mediated role for MMP-13 in the recruitment of platelets to the site of vascular injury and may provide new insights into the association of MMP-13 in atherothrombotic and stroke pathologies.

Keyphrases

cell migration
atrial fibrillation
big data
dna binding
data analysis
tissue engineering