Tumor Microenvironment Remodeling by Intratumoral Oncolytic Vaccinia Virus Enhances the Efficacy of Immune-Checkpoint Blockade.

Hong Jae ChonWon Suk LeeHannah YangSo Jung KongNa Keum LeeEun Sang MoonJiwon ChoiEun Chun HanJoo Hoon KimJoong Bae Ahn

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

Our results show that intratumoral JX treatment induces dramatic remodeling of the TME and more potently suppresses cancer progression with immune-checkpoint blockades by overcoming resistance to immunotherapy.

Keyphrases

papillary thyroid
combination therapy
childhood cancer