Pre- versus post-operative untargeted plasma nuclear magnetic resonance spectroscopy metabolomics of pheochromocytoma and paraganglioma.
Nikolaos G BliziotisLeo A J KluijtmansSebastian SotoGerjen H TinneveltKatharina LangtonMercedes RobledoChristina PamporakiUdo F H EngelkeZoran ErlicJasper EngelTimo DeutschbeinSvenja NöltingAleksander PrejbiszSusan RichterCornelia PrehnJerzy AdamskiAndrzej JanuszewiczMartin ReinckeMartin FassnachtGraeme EisenhoferFelix BeuschleinMatthias KroissRon A WeversJeroen J JansenJaap DeinumHenri J L M TimmersPublished in: Endocrine (2021)
Our study suggests that the pathways of glucose and ketone body homeostasis are affected in PPGL patients. BMI-related metabolite levels were also found to be altered, potentially linking muscle atrophy to PPGL. At baseline, patient metabolomes could be discriminated based on their catecholamine phenotype.