SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation.

Lea JužnićKenneth PeukerAnne StrigliMario BroschAlexander HerrmannRobert HäslerMichael KochLiz MatthiesenYvonne ZeissigBritt-Sabina PetersenAlexander NuberGunnar SchottaVolker NeumeisterTriantafyllos ChavakisThomas KurthMathias LescheAndreas DahlAnne von MässenhausenAndreas LinkermannStefan SchreiberKonrad AdenPhilip C RosenstielAndre Franke Jochen Hampe Sebastian Zeissig

Published in: Gut (2020)

SETDB1 plays an essential role in intestinal epithelial homeostasis. Future work is required to investigate whether rare variants in SETDB1 contribute to the pathogenesis of IBD.

Keyphrases

oxidative stress
copy number
gene expression
current status
ulcerative colitis