Effect of TO901317 on GF to promote the differentiation of human bone marrow mesenchymal stem cells into dopamine neurons on Parkinson's disease.

Miaomiao LiJunqing YangOumei ChengZhe PengYin LuoDongzhi RanYang YangPu XiangHaifeng HuangXiaodan TanHong Wang

Published in: Therapeutic advances in chronic disease (2021)

The induced cells have the function of DA neurons and have the potential to treat PD. TO901317 promoted differentiation of hBMSCs into DA neurons, which may be related to activation of the LXR-ABCA1 signaling pathway.

Keyphrases

induced apoptosis
spinal cord
signaling pathway
endothelial cells
high glucose
cell cycle arrest
pi k akt
epithelial mesenchymal transition
oxidative stress
uric acid
metabolic syndrome
cell death
cell proliferation
climate change