Assessment of the zoonotic potential of atypical scrapie prions in humanized mice reveals rare phenotypic convergence but not identity with sporadic CJD prions.

Alba Marín-MorenoFabienne ReineLaetitia HerzogNaima AronFlorence JaffrézicJean-Luc VilotteHuman RezaeiOlivier AndréolettiDavy MartinVincent Beringue

Published in: The Journal of infectious diseases (2024)

The results obtained suggest a low the zoonotic for AS. Rare adaptation may allow the emergence of prions phenotypically resembling those spontaneously forming in humans.

Keyphrases

late onset
high fat diet induced
type diabetes
human health
early onset
climate change
wild type
clinical evaluation