Role of Cardiorespiratory Fitness and Mitochondrial Energetics in Reduced Walk Speed of Older Adults with Diabetes in the Study of Muscle, Mobility and Aging (SOMMA).
Sofhia V RamosGiovanna DistefanoLi-Yung LuiPeggy M CawthonPhilip A KramerIan J SipulaFiona M BelloTheresa MauMichael J JurczakAnthony J MolinaErin E KershawDavid J MarcinekFrederico G S ToledoAnne B NewmanRussell T HeppleStephen B KritchevskyBret H GoodpasterSteven R CummingsPaul M CoenPublished in: medRxiv : the preprint server for health sciences (2023)
Why did we undertake this study? To determine if mitochondrial energetics and cardiorespiratory fitness contribute to slower walking speed in older adults with diabetes. What is the specific question(s) we wanted to answer? Are mitochondrial energetics and cardiorespiratory fitness in older adults with diabetes lower than those without diabetes? How does mitochondrial energetics and cardiorespiratory fitness impact walking speed in older adults with diabetes? What did we find? Mitochondrial energetics and cardiorespiratory fitness were lower in older adults with diabetes compared to those without diabetes, and energetics, and cardiorespiratory fitness, contributed to slower walking speed in those with diabetes. What are the implications of our findings? Cardiorespiratory fitness and mitochondrial energetics may be key therapeutic targets to maintain or improve mobility in older adults with diabetes.