Identification of new trace related impurities in adenosine products using ultra-high-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry.
Yeming ShenPeilu ZhaiPengxuan XiChen ChenFangjing MouFuxin LiJianye ZhangPublished in: Rapid communications in mass spectrometry : RCM (2020)
A UHPLC/QTOF-MS method was established and used for the separation and characterization of nine trace related impurities of adenosine. Their structures were identified based on the MS and MS/MS spectra and retention times. In addition, the specific MS/MS fingerprints of the monosaccharide glycosyl moieties of the adenosine impurity analogs were summarized.
Keyphrases
- ms ms
- ultra high performance liquid chromatography
- tandem mass spectrometry
- liquid chromatography
- mass spectrometry
- high performance liquid chromatography
- simultaneous determination
- high resolution mass spectrometry
- gas chromatography
- high resolution
- liquid chromatography tandem mass spectrometry
- solid phase extraction
- protein kinase
- molecular docking