Quantification of biochemical PSA dynamics after radioligand therapy with [ 177 Lu]Lu-PSMA-I&T using a population pharmacokinetic/pharmacodynamic model.
Hinke SiebingaBerlinda J de Wit-van der VeenDaphne M V de Vries-HuizingWouter V VogelJeroen J M A HendrikxAlwin D R HuitemaPublished in: EJNMMI physics (2024)
Lu]Lu-PSMA-I&T uptake in salivary glands, kidneys and tumors and revealed a clear declining tumor uptake over treatment cycles. The PKPD model adequately captured individual PSA observations and identified population response rates for the two dosing regimens. Hence, a PKPD modelling approach can guide prediction of treatment response and thus identify patients in whom radioligand therapy is likely to fail.