Total synthesis of dissectol A, using an enediolate-based Tsuji-Trost reaction.
Ruben L H AndringaNittert MarinusDaan V BuntElizabeth R HaidererRobert B AbramovitchChristopher D BrownKyu Y RheeMartin D WitteAdriaan J MinnaardPublished in: Chemical science (2024)
Dissectol A is a rearranged terpene glycoside isolated from several flowering plants. Starting from glucose, the densely functionalized bicyclic structure has been prepared via site-selective oxidation and an intramolecular allylic alkylation reaction with an enediolate as the nucleophile. Despite earlier reports, dissectol A is not effective at inhibiting DevRS signaling in whole-cell Mycobacterium tuberculosis and does not inhibit growth of the bacterium.
Keyphrases
- mycobacterium tuberculosis
- electron transfer
- single cell
- signaling pathway
- cell therapy
- hydrogen peroxide
- blood glucose
- quantum dots
- pulmonary tuberculosis
- adverse drug
- type diabetes
- emergency department
- metabolic syndrome
- arabidopsis thaliana
- bone marrow
- weight loss
- drug induced
- glycemic control
- electronic health record