Antemortem CSF Aβ42/Aβ40 ratio predicts Alzheimer's disease pathology better than Aβ42 in rapidly progressive dementias.

Simone BaiardiSamir Abu-RumeilehMarcello RossiCorrado ZenesiniAnna Bartoletti-StellaBarbara PolischiSabina CapellariPiero Parchi

Published in: Annals of clinical and translational neurology (2018)

The present data support the use of CSF Aβ42/Aβ40 ratio as a biomarker of AD pathophysiology and noninvasive screener for Aβ pathology burden, and its introduction in the research diagnostic criteria for AD.

Keyphrases

multiple sclerosis
electronic health record
cognitive decline
big data
cerebrospinal fluid
risk factors
machine learning
deep learning