Brain gliomas are life-threatening diseases with low survival rates. Early detection and accurate intraoperative location of brain gliomas is vital to improving the prognosis. Herein, we synthesized manganese (Mn)-doped carbon dots (CDs) as magnetic resonance (MR)/optical dual-modal imaging nanoprobes by a one-pot green microwave-assisted route. These ultra-small-sized Mn-doped CDs possess distinct excitation-dependent photoluminescent emissions, high r1 relaxivity, and low cytotoxicity. The in vivo MR imaging and ex vivo optical imaging of mouse brain with tiny glioma demonstrate that the Mn-doped CDs could lead to an enhanced MR T1 contrast effect in the tiny brain glioma region, disclosing the great promise of these Mn-doped CDs as MR/optical dual-modal imaging nanoprobes for detection and intraoperative location of tiny brain gliomas.
Keyphrases
- quantum dots
- high resolution
- magnetic resonance
- contrast enhanced
- visible light
- resting state
- metal organic framework
- white matter
- sensitive detection
- high grade
- functional connectivity
- high speed
- energy transfer
- mass spectrometry
- fluorescence imaging
- highly efficient
- magnetic resonance imaging
- cerebral ischemia
- room temperature
- patients undergoing
- computed tomography
- transition metal
- blood brain barrier
- oxide nanoparticles