Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review.
Sheliza HalaniPanashe E TombindoRyan O'ReillyRafael N MirandaLaura K ErdmanClare L WhiteheadJoanna M BieleckiLauren C RamsayRaphael XimenesJustin BoyleCarsten KruegerShannon WillmottShaun K MorrisKellie E MurphyDilian ToroPublished in: PLoS neglected tropical diseases (2021)
The ZIKV literature in adults was predominantly from the Americas. The most common systemic symptoms were exanthema, fever, arthralgia, and conjunctivitis; GBS was the most prevalent neurological complication. Future ZIKV studies are warranted with standardization of testing and case definitions, consistent co-infection testing, reporting of laboratory abnormalities, separation of adult and pediatric outcomes, and assessing for causation between ZIKV and neurological sequelae.