Investigation of Potential Genetic Biomarkers and Molecular Mechanism of Ulcerative Colitis Utilizing Bioinformatics Analysis.

Jia-Qi ZhangXue WangLin XuZedan ZhangFeng-Yun Wang Xu-Dong Tang

Published in: BioMed research international (2020)

This study provides supportive evidence that DUOXA2, A-SAA, TNIP3, CXCL1, SLC6A14, and CD55 might be used as potential biomarkers for tissue biopsy of UC, especially SLC6A14 and DUOXA2, which may be new targets for UC gene therapy. Moreover, the DUOX2/DUOXA2 and CXCL1/CXCR2 pathways might play an important role in the progression of UC through the chemokine signaling pathway and inflammatory response.

Keyphrases

gene therapy
inflammatory response
bioinformatics analysis
ulcerative colitis
signaling pathway
lipopolysaccharide induced
genome wide
pi k akt
epithelial mesenchymal transition
copy number
gene expression
toll like receptor
lps induced
dna methylation
risk assessment
fine needle aspiration
cell migration