Pramipexole and tolcapone alleviate thermal and mechanical nociception in naive rats.
Anita MihaylovaIlia KostadinovNina DonchevaDelian P DelevHristina Ivanova ZlatanovaPublished in: Folia medica (2022)
Pramipexole and tolcapone reduce mechanical and thermal nociception in naïve rats by enhancing dopaminergic neurotransmission at both spinal and supraspinal levels. In addition, tolcapone stimulates noradrenergic mediation which may contribute to its antinociceptive effect.
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