PPARs and the Development of Type 1 Diabetes.
Laurits J HolmMia Øgaard MønstedMartin Haupt-JørgensenKarsten BuschardPublished in: PPAR research (2020)
Peroxisome proliferator-activated receptors (PPARs) are a family of transcription factors with a key role in glucose and lipid metabolism. PPARs are expressed in many cell types including pancreatic beta cells and immune cells, where they regulate insulin secretion and T cell differentiation, respectively. Moreover, various PPAR agonists prevent diabetes in the non-obese diabetic (NOD) mouse model of type 1 diabetes. PPARs are thus of interest in type 1 diabetes (T1D) as they represent a novel approach targeting both the pancreas and the immune system. In this review, we examine the role of PPARs in immune responses and beta cell biology and their potential as targets for treatment of T1D.
Keyphrases
- type diabetes
- immune response
- mouse model
- single cell
- glycemic control
- transcription factor
- cardiovascular disease
- insulin resistance
- induced apoptosis
- adipose tissue
- blood glucose
- weight loss
- cell cycle arrest
- stem cells
- bariatric surgery
- cancer therapy
- signaling pathway
- drug delivery
- bone marrow
- wound healing
- inflammatory response
- dna binding
- pi k akt