Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy.

Qin XiaYang LiWanting XuChengwei WuHanfei ZhengLiqun LiuLei Dong

Published in: Cell & bioscience (2023)

These findings revealed the complex interconnected role among Smurf1, p62/Nrf2/NBR1, and p62/LC3 axis in determining Nrf2 activation and subsequent clearance of condensates through LLPS mechanism.

Keyphrases

oxidative stress
cell death
signaling pathway
endoplasmic reticulum stress
mass spectrometry
single cell
simultaneous determination
high resolution