Molecular Targets of Genistein and Its Related Flavonoids to Exert Anticancer Effects.
Hee-Sung ChaeRong XuJae-Yeon WonYoung-Won ChinHyungshin YimPublished in: International journal of molecular sciences (2019)
Increased health awareness among the public has highlighted the health benefits of dietary supplements including flavonoids. As flavonoids target several critical factors to exert a variety of biological effects, studies to identify their target-specific effects have been conducted. Herein, we discuss the basic structures of flavonoids and their anticancer activities in relation to the specific biological targets acted upon by these flavonoids. Flavonoids target several signaling pathways involved in apoptosis, cell cycle arrest, mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K)/AKT kinase, and metastasis. Polo-like kinase 1 (PLK1) has been recognized as a valuable target in cancer treatment due to the prognostic implication of PLK1 in cancer patients and its clinical relevance between the overexpression of PLK1 and the reduced survival rates of several carcinoma patients. Recent studies suggest that several flavonoids, including genistein directly inhibit PLK1 inhibitory activity. Later, we focus on the anticancer effects of genistein through inhibition of PLK1.
Keyphrases
- pi k akt
- cell cycle arrest
- signaling pathway
- cell death
- healthcare
- cell proliferation
- public health
- protein kinase
- mental health
- end stage renal disease
- oxidative stress
- tyrosine kinase
- chronic kidney disease
- newly diagnosed
- emergency department
- health information
- high resolution
- ejection fraction
- endoplasmic reticulum stress
- prognostic factors
- social media
- patient reported
- single molecule