The guanine-hypoxanthine permease GhxP of Erwinia amylovora facilitates the influx of the toxic guanine derivative 6-thioguanine.

I T GatchellR B HuntleyNeil P Schultes G S Mourad

Published in: Journal of applied microbiology (2020)

As part of the disease establishment process, E. amylovora synthesizes and exports a toxic guanine derivative 6TG. Our results are counter intuitive and show that EaGhxP, an influx transporter, can move 6TG into cells raising questions regarding the role of 6TG in disease establishment.

Keyphrases

induced apoptosis
oxidative stress
water soluble
cell proliferation
signaling pathway
cell death