Antibodies Against Glutamic Acid Decarboxylase 65 Are Locally Produced in the CSF and Arise During Affinity Maturation.

Michelle BiljeckiKatharina EisenhutEduardo BeltránStephan WinklmeierSimone MaderAnna ThallerPeter EichhornPhilipp SteiningerAndrea Flierl-HechtJan LewerenzTania KümpfelMartin KerschensteinerEdgar MeinlFranziska S Thaler

Published in: Neurology(R) neuroimmunology & neuroinflammation (2023)

GAD65-specific B cells are present in the CNS and represent a sizable fraction of CSF B cells early in the disease course. The anti-GAD65 response in the CSF is polyclonal and shows evidence of antigen-driven affinity maturation required for GAD65 recognition. Our data support the hypothesis that the accumulation of GAD65-specific B cells and plasma cells in the CSF is an important feature of early disease stages.

Keyphrases

induced apoptosis
cerebrospinal fluid
machine learning
deep learning
blood brain barrier
big data
oxidative stress
mass spectrometry
endoplasmic reticulum stress