Quartz crystal microbalance for telomerase sensing based on gold nanoparticle induced signal amplification.

Haitang YangYing LiDingzhong WangYong LiuWei Wei Frank C J M van Veggel Song-Qin LiuPeng Li

Published in: Chemical communications (Cambridge, England) (2019)

A novel circulating-flow quartz crystal microbalance (QCM) biosensing method has been established to detect telomerase. Oligonucleotide-functionalized gold nanoparticles (GNPs-cDNA) have been used to amplify the frequency change, which enable this QCM to be a sensitive biosensor for telomerase activity detection. The detection limit was as low as 37 cells per mL. The assay platform exhibited excellent selectivity.

Keyphrases

label free
gold nanoparticles
induced apoptosis
high throughput
real time pcr
quantum dots
cell cycle arrest
high glucose
diabetic rats
oxidative stress
drug induced
solid state
signaling pathway
cell proliferation
endothelial cells
single cell