Single Nucleotide Variants of Candidate Genes in Aggrecan Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes.

Romain Shanil PereraPoruwalage Harsha DissanayakeUpul SenarathLalith Sirimevan WijayaratneAranjan Lional KarunanayakeVajira Harshadeva Weerabaddana Dissanayake

Published in: PloS one (2017)

SNVs of candidate genes in ACAN metabolic pathway are associated with severity of LDD and Modic changes in patients with chronic mechanical low back pain. Predictions of in-silico functional analysis of significant SNVs are inconsistent.

Keyphrases

minimally invasive
molecular docking
copy number
gene expression
dna methylation
molecular dynamics simulations