Modeling psychological function in patients with schizophrenia with the PANSS: an international multi-center study.
Konstantinos N FountoulakisElena DragiotiAntonis T TheofilidisTobias WiklundXenofon AtmatzidisIoannis NimatoudisErik ThysMartien WampersLuchezar HranovTrayana HristovaDaniil AptalidisRoumen MilevFelicia IfteneFilip SpanielPavel KnytlPetra FurstovaTiina FromHenry KarlssonMaija WaltaRaimo K R SalokangasJean-Michel AzorinJustine BouniardJulie MontantGeorg JuckelIda S HaussleiterAthanasios DouzenisIoannis MichopoulosPanagiotis FerentinosNikolaos SmyrnisLeonidas MantonakisZsófia NemesXenia GondaDora VajdaAnita JuhaszAmresh ShrivastavaJohn WaddingtonMaurizio PompiliAnna ComparelliValentina CoriglianoElmars RancansAlvydas NavickasJan HilbigLaurynas BukelskisLidija I StevovicSanja VodopicOluyomi EsanOluremi OladeleChristopher OsunboteJanusz K RybakowskiPawel WojciakKlaudia DomowiczMaria L FigueiraLudgero LinharesJoana CrawfordAnca-Livia PanfilDaria SmirnovaOlga IzmailovaDusica Lecic-TosevskiHenk TemminghFleur HowellsJulio BobesMaria P Garcia-PortillaLeticia García-AlvarezGamze ErzinHasan KaradağAvinash De SousaAnuja BendreCyril HoschlCristina BrediceanIon PapavaOlivera VukovicBojana PejuskovicVincent RussellLoukas AthanasiadisAnastasia KonstaDan SteinMichael BerkOlivia DeanRajiv TandonSiegfried KasperMarc De HertPublished in: CNS spectrums (2020)
The current study investigated the mental organization and functioning in patients with schizophrenia in relation to different stages of illness progression. It revealed two distinct "cores" of schizophrenia, the "Positive" and the "Negative," while neurocognitive decline escalates during the later stages. Future research should focus on the therapeutic implications of such a model. Stopping the progress of the illness could demand to stop the succession of stages. This could be achieved not only by both halting the triggering effect of positive and negative symptoms, but also by stopping the sensitization effect on the neural pathways responsible for the development of hostility, excitement, anxiety, and depression as well as the deleterious effect on neural networks responsible for neurocognition.