Circulating GDF11 exacerbates myocardial injury in mice and associates with increased infarct size in humans.

Simon KralerCarolina BalbiDaria VdovenkoTetiana Lapikova-BryhinskaGiovanni G CamiciLuca LiberaleNicole BonettiCandela Diaz CanestroFabienne BurgerAline RothFederico CarboneGiuseppe VassalliFrançois MachShalender BhasinFlorian A WenzlOlivier Müller Lorenz RäberChristian M MatterFabrizio Montecucco Thomas Felix Lüscher Alexander Akhmedov

Published in: Cardiovascular research (2023)

Our data challenge the initially reported rejuvenating effects of circulating GDF11 and suggest that high levels of systemic GDF11 exacerbate myocardial injury in mice and humans alike. Our results suggest that persistently high GDF11 levels during ageing may contribute to the age-dependent loss of cardioprotective mechanisms and thus poor outcomes following acute MI.

Keyphrases

high fat diet induced
liver failure
acute myocardial infarction
drug induced
electronic health record
type diabetes
respiratory failure
intensive care unit
big data
machine learning
extracorporeal membrane oxygenation
percutaneous coronary intervention
mechanical ventilation