Beneficial Role of HO-1-SIRT1 Axis in Attenuating Angiotensin II-Induced Adipocyte Dysfunction.

Hari Vishal LakhaniMishghan ZehraSneha S PillaiNitin PuriJoseph I ShapiroNader G AbrahamKomal Sodhi

Published in: International journal of molecular sciences (2019)

Our study demonstrates for the first time that HO-1 has the ability to restore cellular redox, rescue SIRT1, and prevent AngII-induced impaired effects on adipocytes and the systemic metabolic profile.

Keyphrases

angiotensin ii
oxidative stress
diabetic rats
high glucose
adipose tissue
drug induced
vascular smooth muscle cells
angiotensin converting enzyme
ischemia reperfusion injury
insulin resistance
type diabetes
cell proliferation
signaling pathway