Effect of HIV status and retinol on immunogenicity to oral cholera vaccine in adult population living in an endemic area of Lukanga Swamps, Zambia.
Charlie Chaluma LuchenJohn MwabaHarriet Ng'ombePeter Ibukun Oluwa AlabiMichelo SimuyandiObvious N ChilyabanyamaLuiza Miyanda HatyokaCynthia MubangaSamuel BosomprahRoma ChilengiCaroline Cleopatra ChisengaPublished in: PloS one (2021)
Our results show that while Shanchol™ is immunogenic in both HIV+/- individuals, HIV + participants responded poorly. Viral load and CD4 count affected vaccine immunogenicity. More research is required for detailed understanding of this in order to appropriately inform policy and practice.