Deletions on Chromosome Y and Downregulation of the SRY Gene in Tumor Tissue Are Associated with Worse Survival of Glioblastoma Patients.
Małgorzata ŁysiakAnja SmitsKenney Roy RoodakkerElisabeth SandbergAnna DimbergMunila MudaisiCharlotte BratthällMichael StrandeusPeter MilosMartin HallbeckPeter SöderkvistAnnika MalmströmPublished in: Cancers (2021)
Our data show that deletions and reduced gene expression of chromosome Y genes, especially SRY, are associated with reduced survival of male GBM patients and connected to major susceptibility pathways of gliomagenesis.