Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults.

Anne van RongenMargreke J E BrillJanelle D VaughnsPyry A J VälitaloEric P A van DongenBert van RamshorstJeffrey S BarrettJohannes N van den AnkerCatherijne A J Knibbe

Published in: Clinical pharmacokinetics (2019)

We hypothesise that higher midazolam clearance in obese adolescents is explained by less obesity-induced suppression of CYP3A activity, while the increase with WTexcess is explained by increased liver blood flow. The approach characterising the influence of obesity in the paediatric population we propose here may be of value for use in future studies in obese adolescents.

Keyphrases

weight loss
metabolic syndrome
bariatric surgery
obese patients
young adults
blood flow
type diabetes
adipose tissue
insulin resistance
physical activity
emergency department
weight gain
high fat diet induced
endothelial cells
skeletal muscle
case control