The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways Regulate Stemness and Metastatic Potential in Colorectal Cancer Cells.

Teruaki Fujishita Yasushi Kojima Rie Kajino-Sakamoto Emi Mishiro-Sato Yasuhiro Shimizu Waki Hosoda Rui Yamaguchi Makoto Mark Taketo Masahiro Aoki

Published in: Cancer research (2022)

This study identifies signaling pathways essential for maintaining the stemness and metastatic potential of colorectal cancer cells and proposes CREB as a therapeutic target in metastatic colorectal cancer.

Keyphrases

epithelial mesenchymal transition
metastatic colorectal cancer
transforming growth factor
stem cells
squamous cell carcinoma
small cell lung cancer
signaling pathway
genome wide
human health
binding protein
gene expression
dna methylation
climate change