Mitochondria-targeted antioxidant MitoQ ameliorates ischaemia-reperfusion injury in kidney transplantation models.

Mazin HamedA LoganA V GruszczykT E BeachA M JamesA J DareA BarlowJ MartinN GeorgakopoulosA M GaneK CrickD FoutoC FearS ThiruN DolezalovaJ R FerdinandM R ClatworthySarah A HosgoodM L NicholsonM P MurphyK Saeb-Parsy

Published in: The British journal of surgery (2021)

Mitochondria-targeted antioxidant MitoQ can be administered to ischaemic kidneys simply and effectively during cold storage, and may improve outcomes after transplantation.

Keyphrases

kidney transplantation
oxidative stress
cancer therapy
anti inflammatory
cell death
reactive oxygen species
endoplasmic reticulum
acute myocardial infarction
cerebral ischemia
mouse model
cell therapy
heart failure
coronary artery disease
acute coronary syndrome