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Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity.

Stephen R DoyleCatherine BourguinatHugues C Nana-DjeungaJonas A Kengne-OuafoSébastien D S PionJean BopdaJoseph KamgnoSamuel WanjiHua CheAnnette C KueselMartin WalkerMaria-Gloria BasáñezDaniel A BoakyeMike Y Osei-AtweneboanaMichel BoussinesqRoger K PrichardWarwick N Grant
Published in: PLoS neglected tropical diseases (2017)
This study is one of the first genome-wide association analyses in a parasitic nematode, and provides insight into the genomics of ivermectin response and population structure of O. volvulus. We argue that ivermectin response is a polygenically-determined quantitative trait (QT) whereby identical or related molecular pathways but not necessarily individual genes are likely to determine the extent of ivermectin response in different parasite populations. Furthermore, we propose that genetic drift rather than genetic selection of SOR is the underlying driver of population differentiation, which has significant implications for the emergence and potential spread of SOR within and between these parasite populations.
Keyphrases
  • genome wide
  • genome wide analysis
  • copy number
  • genome wide association
  • emergency department
  • high resolution
  • drug administration
  • single cell
  • drug induced
  • adverse drug
  • electronic health record