Epitope screening using Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS): An accelerated workflow for evaluation of lead monoclonal antibodies.

Shaolong Zhu Peter LiuniTricia ChenCamille HouyDerek J Wilson D Andrew James

Published in: Biotechnology journal (2021)

An accelerated HDX-MS epitope screening workflow was developed. The "screening" workflow successfully characterized five (out of six attempted) novel epitopes on the PRN antigen; information that can be used to support vaccine antigenicity assays.

Keyphrases

mass spectrometry
multiple sclerosis
electronic health record
ms ms
liquid chromatography
healthcare
gas chromatography
high performance liquid chromatography
health information
social media
single cell