Traditional Chinese Formula Xiaoyaosan Alleviates Depressive-Like Behavior in CUMS Mice by Regulating PEBP1-GPX4-Mediated Ferroptosis in the Hippocampus.

Haiyan JiaoHongjun YangZhiyi YanJianbei ChenMengbai XuYouming JiangYueyun LiuZhe XueQing-Yu MaXiaojuan LiJiaxu Chen

Published in: Neuropsychiatric disease and treatment (2021)

Our results revealed that the activation of ferroptosis might exist in the hippocampi of CUMS-induced mice. The PEBP1-GPX4-mediated ferroptosis could be involved in the antidepressant mechanism of Xiaoyaosan. It also implied that ferroptosis could become a new target for research into the depression mechanism and antidepressant drugs.

Keyphrases

cell death
major depressive disorder
high fat diet induced
diabetic rats
drug induced
mouse model
oxidative stress
cognitive impairment