Structural signature of sporadic Creutzfeldt-Jakob disease.
J NavidG S DayJ StrainR J PerrinR C BucelliA DincerJ K WischDavid N Soleimani-MeigooniJ C MorrisT L S BenzingerBeau M AncesPublished in: European journal of neurology (2019)
Cortical signature changes in sCJD may reflect brain changes not captured by standard clinical measures. This information may be used with clinical measures to inform the progression of sCJD and patterns of prion protein spread throughout the brain. These results may have implications for prediction of symptomatic progression and plausibly for development of therapeutic strategies.