Signs of early cellular dysfunction in multiple system atrophy.

M Herrera-VaqueroAntonio Heras-GarvinF KrismerR DeleanuS BoeschG K WenningNadia Stefanova

Published in: Neuropathology and applied neurobiology (2020)

Our results show early cellular dysfunction in MSA-derived NPCs. We identified changes in the redox homeostasis which are functionally compensated at baseline but cause increased susceptibility to exogenous oxidative stress. In addition, nuclear translocation of α-synuclein in MSA-derived NPCs supports an early cellular stress response which may precede the neurodegenerative process in this disorder.

Keyphrases

oxidative stress
dna damage
ischemia reperfusion injury
induced apoptosis
signaling pathway
heat shock