Expression Profile of Six RNA-Binding Proteins in Pulmonary Sarcoidosis.

Zdenka NavratilovaEva NovosadovaMichael Hagemann-JensenSusanna KullbergVitezslav KolekJohan GrunewaldMartin Petrek

Published in: PloS one (2016)

mRNA expressions of three RBPs (AUF1, TIA and NCL) and their potential target mRNA encoding RECK in BA cells and additionally protein expression of AUF1 and HuR in PBTLs were down-regulated in our sarcoidosis patients compared to healthy individuals. Its significance, e.g. for stability of mRNAs encoding pro-inflammatory factors, should be further explored in sarcoidosis.

Keyphrases

end stage renal disease
binding protein
ejection fraction
induced apoptosis
newly diagnosed
peritoneal dialysis
transcription factor
cell cycle arrest
signaling pathway
patient reported outcomes
cell death
cell proliferation
human health