Cell-Type Profiling of the Sympathetic Nervous System Using Spatial Transcriptomics and Spatial Mapping of mRNA.
Jennifer C Kasemeier-KulesaJason A MorrisonSean McKinneyHua LiMadelaine GogolKate HallShiyuan ChenYongfu WangAnoja PereraRebecca McLennanPaul M KulesaPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2023)
Together, these data demonstrate a robust strategy to acquire and integrate single cell and spatial transcriptomic information, resulting in improved resolution of molecular heterogeneities in complex neural tissue architectures. Successful application of this strategy to the developing SNS provides a roadmap for functional studies of neural connectivity and platform to address complex questions in neural development and regeneration. This article is protected by copyright. All rights reserved.