Variable DNA methylation of aging-related genes is associated with male COPD.

Xizi DuLin YuanMengping WuMeichao MenRuoxi HeLeyuan WangShuangyan WuYang XiangXiangping QuHuijun LiuXiaoqun QinChengping HuLing QinChi Liu

Published in: Respiratory research (2019)

These results identified that the mRNA expression and DNA methylation level of aging-related genes were changed in male COPD patients, which provides a molecular link between aging and COPD. The identified CpG markers are associated with the severity of COPD and provide new insights into the prediction and identification of COPD.

Keyphrases

chronic obstructive pulmonary disease
dna methylation
lung function
gene expression
end stage renal disease
newly diagnosed
ejection fraction
cystic fibrosis
air pollution
peritoneal dialysis
copy number
patient reported