Effect of intravenous pulses of methylprednisolone 250 mg versus dexamethasone 6 mg in hospitalised adults with severe COVID-19 pneumonia: An open-label randomised trial.

Luis Corral Gudino Ivan Cusacovich Jose Ignacio Martin-Gonzalez Alberto Muela-Molinero Jessica Abadía Otero Roberto Gonzalez-Fuentes Ángela Ruíz-de-Temiño Elena Tapia-Moral Francisca Cuadrado-Medina Miguel Martín-Asenjo José Pablo Miramontes González Jose Luis Delgado-González Sandra Ines Laura Abad-Manteca Iciar Usategui-Martín Tomás Ruiz Sara Miranda-Riaño Patricia Rodríguez-Fortúnez Consuelo Rodríguez-JiménezEsperanza López-FrancoMiguel Marcosnull null

Published in: European journal of clinical investigation (2022)

Among severe but not critical patients with COVID-19, 250 mg/d for 3 days of methylprednisolone compared with 6 mg/d for 10 days of dexamethasone did not result in a decrease in mortality or intubation.

Keyphrases

high dose
low dose
coronavirus disease
sars cov
early onset
cardiovascular events
clinical trial
open label
community acquired pneumonia
double blind
respiratory syndrome coronavirus