Duration of Morning Hyperinsulinemia is Key to the Enhancement of Hepatic Glucose Uptake and Glycogen Storage Later in the Day.

Morning insulin exposure primes the liver for increased hepatic glucose uptake and glycogen storage during a subsequent meal. This study addressed whether the pattern and/or duration of meal-associated insulin delivery in the morning influences insulin's ensuing priming effect. We found that in the morning, a smaller amount of insulin delivered over a longer duration is more effective than a larger amount over a shorter duration in improving liver glucose metabolism in the afternoon.