Mechanisms involved in the antidepressant-like action of orally administered 5-((4-methoxyphenyl)thio)benzo[c][1,2,5]thiadiazole (MTDZ) in male and female mice.

Karline da Costa RodriguesMeliza da Conceição OliveiraBeatriz Fuzinato Dos SantosNelson Luís de Campos DominguesMariana Gallio FronzaLucielli SavegnagoEthel Antunes WilhelmCristiane Luchese

Published in: Psychopharmacology (2024)

These findings suggest that MTDZ may serve as a promising antidepressant agent due to its selective inhibition of MAO-A and the involvement of serotonergic and NO pathways.

Keyphrases

major depressive disorder
bipolar disorder
high fat diet induced
type diabetes
metabolic syndrome
skeletal muscle
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