Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog.
Aroon D HingoraniJasmine GrattonChris FinanA Floriaan SchmidtRiyaz PatelReecha SofatValerie KuanClaudia LangenbergHarry HemingwayJoan K MorrisNicholas J WaldPublished in: BMJ medicine (2023)
Polygenic risk scores performed poorly in population screening, individual risk prediction, and population risk stratification. Strong claims about the effect of polygenic risk scores on healthcare seem to be disproportionate to their performance.
Keyphrases