Immune-mediated axonal dysfunction in seropositive and seronegative primary Sjögren's syndrome.
Jowy TaniHsien-Tzung LiaoHui-Ching HsuLung-Fang ChenTsui-San ChangCindy Shin-Yi LinJia-Ying SungPublished in: Annals of clinical and translational neurology (2020)
Anti-SSA/Ro and anti-SSB/La autoantibodies might cause dysfunction in nodal and internodal region of the axon and small nerve fibers; meanwhile, autoreactive antibodies in seronegative pSS mainly affect small nerve fibers. Thus, the underlying pathophysiology for the two types of pSS is different.