Cerebrospinal fluid cyto-/chemokine profile during acute herpes simplex virus induced anti-N-methyl-d-aspartate receptor encephalitis and in chronic neurological sequelae.
Kavitha KothurDeepak GillMelanie WongShekeeb S MohammadSushil BandodkarSusan ArbunckleLouise WienholtRussell C DalePublished in: Developmental medicine and child neurology (2017)
HSE-induced anti-NMDAR encephalitis is a complex and pronounced inflammatory syndrome. There is persistent CSF upregulation of cyto-/chemokines in chronic or relapsing post-HSE neurological symptoms, which may be modifiable with immune therapy. The elevated cyto-/chemokines may be targets of monoclonal therapies.
Keyphrases
- drug induced
- cerebrospinal fluid
- herpes simplex virus
- high glucose
- diabetic rats
- multiple sclerosis
- oxidative stress
- liver failure
- case report
- endothelial cells
- signaling pathway
- systemic lupus erythematosus
- aortic dissection
- mesenchymal stem cells
- brain injury
- long non coding rna
- cerebral ischemia
- binding protein
- subarachnoid hemorrhage
- replacement therapy