Tandem ring-opening and formal [3 + 2] cycloaddition of furo[2,3- d ]pyrimidine-2,4-diones.

The base promoted tandem annulation reaction of activated cyclic 1,3-dipolarophiles such as 2-arylidene-1,3-indanediones, 2-( o -hydroxybenzylidene)-1,3-indanediones and 3-methyleneoxindoles with functionalized furo[2,3- d ]pyrimidine-2,4-diones was systematically investigated. This reaction provided efficient synthetic protocols for complex dispiro/dispiro fused tricyclic compounds including dispiro[indene-2,3'-cyclopentane-1',5''-pyrimidines], dispiro[indoline-3,3'-cyclopentane-1',5''-pyrimidines] and spiro[cyclopenta[ c ]indeno[1,2- b ]chromene-3,5'-pyrimidines] in good yields and with high diastereoselectivity. The reaction was believed to proceed via sequential ring-opening of the furyl ring, formal [3 + 2] cycloaddition and annulation of the o -hydroxyphenyl group.