Integrated Network Pharmacology Analysis and Experimental Validation to Elucidate the Mechanism of Acteoside in Treating Diabetic Kidney Disease.
Shu Jiao ZhangYi Fei ZhangXue Hui BaiMeng Qi ZhouZe Yu ZhangShuai Xing ZhangZi Jing CaoLin WangShao Wei DingHui Juan ZhengYu Ning LiuGuo Yong YuWei Jing LiuPublished in: Drug design, development and therapy (2024)
Acteoside demonstrates renoprotective effects in DKD by regulating the PI3K/AKT/NF-κB signaling pathway and alleviating pyroptosis. This study explores the pharmacological mechanism underlying acteoside's efficacy in DKD treatment, providing a foundation for further basic and clinical research.