Sex differences in pre- and post-synaptic glutamate signaling in the nucleus accumbens core.

Melissa C KnouseAndre U DeutschmannMiroslav N NenovMathieu E WimmerLisa A Briand

Published in: Biology of sex differences (2023)

We conclude that there are baseline sex differences in synaptic plasticity and excitatory transmission in the nucleus accumbens core. Our data suggest there are sex differences at multiple levels in this region that should be considered in the development of pharmacotherapies to treat psychiatric illnesses such as depression and substance use disorder.

Keyphrases

mental health
depressive symptoms
electronic health record
sleep quality
big data
prefrontal cortex
deep learning