Discovery of pyrrolo[2,1- f ][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain.

Carolyn D DzierbaBireshwar DasguptaGeorge KarageorgeWalter KostichBrian HammanJason AllenKim M EspositoRamesh PadmanabhaJames GraceKimberley LentzJohn MorrisonDaniel MorganAmy EastonClotilde BourinMarc R BrowningRamkumar RajamaniAndrew GoodDawn D ParkerJodi K MuckelbauerJaved KhanDaniel CamacKaushik GhoshVivek HalanJonathan S LippyKenneth S SantoneR Rex DentonRyan WestphalLinda J BristowCharles M ConwayJoanne J BronsonJohn E Macor

Published in: Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents (2023)

Keyphrases

chronic pain
small molecule
pain management
protein protein
tyrosine kinase
amino acid
mass spectrometry
high resolution